Event, Conference or Meeting

The First International Conference on Sustainable Livestock Development: Challenges and Opportunities. Section II: Livestock Improvement and Sustainability, Talk title: Alternative Paradigm in Biotechnology: Molecular Biomimetics Potential Applications within the One Health Framework

Alternative Paradigm in Biotechnology: Molecular Biomimetics Potential Applications within the One Health Framework

Hossam E. M. Sayour

Molecular Biomimetics Research Group Leader, Biomedical Chemistry Research Unit, Chemistry Dept., Animal Hearth Institute, WOAH’s Regional Center for Bacterial Diseases & AMR in Africa, Agricultural Research Center, 7, Nadi El-Sied T., Dokki 12618, Giza, Egypt

Abstract:

Molecular biomimetics merges biology with engineering through inspirating nature's building blocks for designing creative smart materials-based innovative solutions as an alternative paradigm far from classical biotechnology. In the merits of state-of-the-art frontenis’s sciences, these creative solutions could be the magic touch for many of the one health catastrophic problems connecting the health of humans, animals, and the environment could be solved. In chemistry molecularly imprinted polymers (MIPs) act like synthetic, highly durable "antibodies" engineered as a custom-made to lock onto specific target molecules lately IUPAC call it “plastic antibodies”. MIPs can be designed and tailored to capture wide scope sized molecules with specific molecular recognition; starting from cationic or anionic elements, small molecules of biomarkers/drugs/pesticides/herbicides/toxins/pollutants up to epitopes of antigenic determinants of microorganisms (virus, bacteria, fungus, parasite) higher to whole cell, antibiotic resistance (AMR) by trapping specific bacterial communication signals to stop bacteria from gathering and forming drug-resistant films. Potential applications include tailored bio/sensor development, point of care/need testing devices, drug delivery, specific separation tools, artificial enzymes and gathering one or more of multipurposed applications of the previously mentioned categorical solutions. The World Health Organization (WHO) investigates MIPs for use in cheap, fast health tests and detecting dangerous diseases. The World Organization for Animal Health (WOAH) supports the use of these technologies to track diseases and ensure food safety across the agricultural supply chain. The Food and Agricultural Organization (FAO), European Food Safety Authority (EFSA) and Food and Drug Administration (FDA) highlights and do endorse MIPs for the analytical methods used to test for contaminants. The Environmental Protection Agency (EPA) uses MIP research to isolate toxic "priority pollutants" from water supplies.

Keywords:

 Molecular biomimetics, plastic antibodies, nanobiotechnology, smart materials, one health framework, AI based applications, molecular imprinting, theragnostic applications, food safety, environmental protection, precision medicine, smart farming, plant protection, point of care devises, biomimetic sensors, smart delivery, infectious zoonotic diseases

References:

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