I'm new to MIP research and struggling to find any research papers that mention the rate at which molecules unbind from imprinted polymers, especially in regards to a timescale. If anyone has any information or links to research papers which could help it would be much appreciated.
as spam or for offensive content
On 20 March 2020 at 12:47:38 Mike Whitcombe replied:
Hi Sarah, for a homogeneous population of binding sites the binding or association constant (Ka) = (kon / koff) - the on and off rates. The dissociation constant (Kd) is the inverse of this. So measuring Ka and the binding rate allows you to calculate koff. Bear in mind however that MIPs are not generally homogeneous binders. I hope this helps. Can anyone else help Sarah? Mike Whitcombe (SMI President)
as spam or for offensive content
you need to be logged in to post a reply to this posting