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Forum: SMI Website Topic: Questions Thread: New to MIP research

 On 4 March 2020 at 13:08:11 Sarah Cameron said:

I'm new to MIP research and struggling to find any research papers that mention the rate at which molecules unbind from imprinted polymers, especially in regards to a timescale. If anyone has any information or links to research papers which could help it would be much appreciated.
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On 20 March 2020 at 12:47:38 Mike Whitcombe  replied:

Hi Sarah, for a homogeneous population of binding sites the binding or association constant (Ka) = (kon / koff) - the on and off rates. The dissociation constant (Kd) is the inverse of this. So measuring Ka and the binding rate allows you to calculate koff. Bear in mind however that MIPs are not generally homogeneous binders. I hope this helps. Can anyone else help Sarah? Mike Whitcombe (SMI President)
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